Available: http://www.cdc.gov/niosh/npg/npgd0103.html [accessed August 2013]. Groups of two male ChR-CD rats were exposed to carbonyl fluoride by inhalation at nominal concentrations of 5 or 10 ppm and a group of six rats was exposed at 100 ppm for 4 h. Three rats exposed at 100 ppm died, and pathologic examination showed they had acute tracheobronchitis and pulmonary congestion. Total Protein PC LPO 200 150 100 50 0 6 4 2 0 mg / gm lens Group-1 Group-2 Group-3 Group-4 Group-1 Group-2 Group-3 Group-4 Group-1 Group-2 Group-3 Group-4 a a a ab ab abc ab n mol carbonyl content / mg protein ab n mol MDA/gm tissue 6 4 2 0 DuPont (E.I. 13(3):301-309. At higher concentrations (26.7 ppm and higher for 4 h), death occurred indicating a steep exposure-response curve (DuPont 1976). 32-59. 1216. International Programme on Chemical Safety and the Commission of the European Communities [online]. It is hygroscopic, and is hydrolyzed by water (HSDB 2009). HHS At concentrations of 26.7 ppm or higher for 4 h death occurred (DuPont 1976). Extremely hazardous substances can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. 8EHQ-1092-11415. An interspecies uncertainty factor of 3 was applied, because the toxicity of a direct-acting irritant in not expected to differ greatly among species. That approach is justified because carbonyl fluoride appears to have a steep concentration-. Fabrication de produits organiques Hygiène et sécurité Apparence . No. J. Odour : Pungent. Prolonged exposure of the containers to fire or heat may result in violent rupturing and rocketing. On day 1 and 5 of the exposure period, and 3, 7, and 18 days postexposure urine samples were collected and examined for fluoride excretion and glucose, protein, and ketones. Hydrogen fluoride is soluble in water and is absorbed by the respiratory tract (HSDB 2012). However, individual data and photomicrographs of the lungs were not provided for those species. Epub 2009 Sep 13. The metabolic inhibition was reversible, as were the pathologic changes in the lungs (with the exception of a small amount of emphysematous change), liver, and kidneys (examined 18 days after exposure). In case of fire in the surroundings, use appropriate extinguishing … Carbonyl fluoride: 300 ft: 0.4 mi: 1.4 mi: 2000 ft: 2.2 mi: 5.1 mi: Carbonyl fluoride, compressed: 300 ft: 0.4 mi: 1.4 mi: 2000 ft: 2.2 mi: 5.1 mi: The ERG doesn't predict that large amounts of toxic-by-inhalation gases will be produced if this material is spilled in water. Available: http://www.lasrook.net/lasrookNL/maclijst2004.htm [accessed June 24, 2014]. (1968a). Available: http://www.dtic.mil/dtic/tr/fulltext/u2/714694.pdf [accessed june 23, 2014]. The low concentration of 2.5 ppm was not lethal to the rats and no clinical signs developed. Hazards What is this information? Give artificial respiration if not breathing. Atmospheres were generated with a metered air stream into the exposure chamber, and concentrations were measured by the hydrolysable fluoride method. Extravasation of red cells from damaged capillaries continued for up to 7 days; the effect was accompanied by mild interstitial fibrosis. NRC (National Research Council). 20(3): 247-255. Data adequacy: Data on carbonyl fluoride were inadequate for deriving AEGL-2 values, so values were estimated by dividing the AEGL-3 values by 3. Rats from both sexes were exposed for durations of 5 and 10 min to nominal concentrations of 10,000 to 57,000 ppm HF or 500 to 10,000 ppm COF2. Ind. Carbonyl fluoride; Utilisation et sources d'émission. Eighteen days after the last exposure, the urinary fluoride concentration was four times that of controls. TABLE 2-2 Chemical and Physical Properties of Carbonyl Fluoride, Carbon difluoride oxide; carbon fluoride oxide; carbonic difluoride; carbon oxyfluoride; carbonyl fluoride, difluoroformaldehyde; fluophosgene; fluoroformyl fluoride; fluorophosgene, Unstable in presence of water, very hygroscopic, 1 ppm = 2.7 mg/m3 American Conference of Government and Industrial Hygienists, Cincinnati, OH. 3.4. Haskell Laboratory Report No. Carbonyl fluoride | + OHS Research. 4.4.3. The authors stated that those effects were produced at the same concentration in other species, including the dog, rabbit, guinea pig, and mouse, although individual data and photomicrographs of the lungs were not provided for those species. An intraspecies uncertainty factor of 3 was applied because carbonyl fluoride is a direct-acting irritant of the lungs and its effects are not expected to differ greatly among individuals. Carbonyl fluoride agent detailed information in Haz-Map database. 353-50-4). aTLV-TWA (threshold limit value – time-weighted average, American Conference of Governmental Industrial Hygienists) (ACGIH 2012) is the time-weighted average concentration for a normal 8-h workday and a 40-h workweek to which nearly all workers may be repeatedly exposed, day after day, without adverse effect. with your help ... Sources of Fluoride; Infant Exposure; Environmental Justice; Pollution; Politics; F.A.Q. The 30-min AEGL-3 value was adopted for the 10-min value in accordance with the standing operating procedures for developing AEGL values (NRC 2001). The calculated BMC01 was 10.4 ppm and the BMCL05 was 5.2 ppm (DuPont 1976). OTS0571353. The NAC reviewed and revised the document and AEGLs as deemed necessary. Exposure of rats to carbonyl fluoride at 310 ppm resulted in focal hemorrhage of the lungs and pulmonary edema, observed 24 h after exposure. Carbonyl fluoride is a colorless and irritating gas, with a pungent odor. The 4-h LC50 (lethal. The concentration-exposure duration relationship for many irritant and systemically-acting vapors and gases can be described by the equation Cn × t = k, where the exponent n ranges from 0.8 to 3.5 (ten Berge et al. For polytetrafluoroethylene, pyrolysis products include a number of highly toxic compounds in addition to carbonyl fluoride, including perfluoroisobutylene, which is approximately 10-fold more toxic than phosgene (Patocka and Bajgar 1998; IPCS 2004). The concentration-exposure duration relationship for many irritant and systemically acting vapors and gases may be described by the equation Cn × t = k, where the exponent ranges from 0.8 to 3.5 (ten Berge et al. TABLE 2-1 AEGL Values for Carbonyl Fluoride. Carbonyl fluoride can be prepared from fluorine or bromine trifluoride and carbon monoxide. Carbonyl fluoride is unstable in the presence of water, hydrolyzing to carbon dioxide and hydrogen fluoride: [2] COF 2 + H 2 O → CO 2 + 2 HF Safety. Hyg. Show this book's table of contents, where you can jump to any chapter by name. 29(1):41-48. Experiments were undertaken to compare morbidity and mortality from brief inhalation exposures to high levels of hydrogen fluoride (HF) and carbonyl fluoride (COF2). It has a relatively low dissociation constant (3.5 × 10-4), which allows the non-ionized compound to penetrate the skin, respiratory system, or gastrointestinal tract. Liver congestion and bright red spleens were also exposed to the next one other aspects. The rats and DERIVATION of a short-term exposure experiments conclude carbonyl fluoride inhalation COF2 is nearly 45 times lethal. Nrc ( 2001 ), is applicable for Chemicals with steep concentration-response curve loss occurred subsequent to.. 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